Advisor, Upstream Process Development
Eli Lilly and Company
January 2023 – Present
o Leading the design and execution of upstream process development studies in baculovirus/Sf9 systems for AAV gene therapy drug substances in benchtop scale bioreactors
o Developing platform process to screen and optimize process conditions for new pipeline products
o Assisting research material generation needs for new pipeline products
o Providing technical expertise in cell culture scale-up, bioreactor process parameters, process control strategy, and media additive strategies
o Building process understanding to support technology transfer to internal or external groups for manufacturing at pilot, engineering, clinical, or commercial scales
o Developing new production lab to scale up AAV production for rare disease treatment
Graduate Research Assistant
3D-Tissue Manufacturing Research Group at NC State
December 2019 – December 2022
o Evaluated differentiation of stem cells (hASCs) in 3D scaffolds and hydrogels using nondestructive techniques
o Worked with various mammalian cell lines (hASCs, Chondrocytes, 3T3, MG63, C2C12) and E. Coli
o Developed novel nondestructive quality evaluation system for engineered tissue constructs
o Planned and executed designed experiments to systematically characterize CQA of impedance spectroscopy.
o Analyzed the Dielectric Spectroscopy signals by developing a custom-coded python script for quality monitoring
o Evaluated the patterns associated with engineered tissues using machine learning and deep learning algorithms
o Developed a GUI using python to track the historical quality attributes automatically for long term studies
o Developed scalable multi-modal perfusion based novel tissue bioreactor system for quality monitoring
o Co-authored 3 poster presentations, 5 oral presentations, 1 conference proceeding, and 4 working manuscripts.
Laboratory Manager
3D-Tissue Manufacturing Research Group at NC State
April 2021 – December 2022
o Optimized laboratory inventory, ordering, and stocking workflows for BSL-2 cell culture lab.
o Liasoned with life science sales representatives to plan capital purchases and lead product demonstrations.
o Represented 3D-Tissue Manufacturing Research Group at cross-functional and institute meetings.
Graduate Teaching Assistant at NC State
August 2018 – December 2019
o Assisted students on their class lectures, assignments, and projects through office hours and one-on-one communication
Associate Member Principal Investigator
Comparative Medicine Institute at NC State
January 2021 – July 2021
· Secured and managed $8,000 in internal research capital through NIH-style grant application
· Built cross-functional teams of material scientists, engineers, cell biologists to achieve project goals
· Managed and mentored undergrad students in collaborative team science environment
Society for Manufacturing Engineers (SME) Student Chapter, ISE, NCSU
President
April 2021 – April 2022
Coordinated factory visits and info sessions with local companies for undergrad and graduate engineering students
Vice President
April 2020 – April 2021
Coordinated online info sessions for undergrad and graduate engineering students
Comparative Medicine Institute at NC State
2019 – 2022
FTE Associate Member
Designed strategies for engaging CMI members across social media platforms and mentored undergrads
Institute of Industrial and Systems Engineers
March 2021 – 2022
Student Member